to change the view on the use of NMR for the study of chemical reactions.

At present, NMR as a tool for analysis of reaction mixtures is receding into the background, yielding this role to the LC-MS method, which does not require long-term sample preparation and makes it possible to reveal the peak of the product by the mass of the molecular ion. Despite the very high information content, the use of NMR in routine studies is currently limited by the high cost of deuterated solvents and the time spent on processing the reaction mixtures.

At a solvent cost of less than $ 1-3 per sample, the reaction can be carried out in a deuterated solvent, analyzed without a processing step, which makes it possible to look into the reaction mixture and gain a more complete picture of the ongoing processes, while saving synthetic time.